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Search Results for " melanocortin receptor "

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Cat. No.	Product Name	Target	Signaling Pathways
T8485	THIQ	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	THIQ 是一种选择性黑皮质素 4 受体 (MC4R) 激动剂，对 hMC4R 和 rMC4R 的 IC50 分别为 1.2 和 0.6 nM。
TP1898	HS024 HS 024	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	HS024 是一种选择性的MC4受体拮抗剂，可增加食物摄入，对 MC4、MC5、MC3 和 MC1 的Ki 分别为 0.29、3.29、5.45 和 18.6 nM。
T7589	Afamelanotide acetate afamelanotide	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Afamelanotide acetate 是一种合成的 α-黑素细胞刺激激素类似物和一流的黑皮质素-1 受体激动剂，用于治疗红细胞生成性原卟啉症。
TP1889	MCL0020 MCL 0020	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	MCL0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂，IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症，在体内表现出抗焦虑样活性。
T5464	JNJ-10229570 JNJ10229570,UNII-N9IX402L35,JNJ 10229570	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	JNJ-10229570 (UNII-N9IX402L35) 是肾上腺皮质受体 1 和肾上腺皮质受体 5 的拮抗剂，可抑制皮脂腺分化和皮质特异性脂质的产生，其抑制125I-NDP-α-MSH 和人类细胞中 MC1R 和 MC5R 结合的IC50值分别为 270 nM 和 200 nM。
T7608	Bremelanotide Acetate bremelanotide,PT-141 Acetate	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Bremelanotide Acetate (PT-141 Acetate) 是 α-MSH 的合成肽类似物，是黑素皮质素受体 MC3R 和 MC4R 的激动剂，有用于性功能障碍的研究潜力。
TP1097	Melanotan I 美拉诺坦,美拉诺坦 I,[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I	Others	Others
	Melanotan I 是一种非特异性黑素皮质激素受体 (MCR) 激动剂，是一种 α- 黑素细胞刺激激素 (α-MSH) 类似物，皮下注射可增加黑色素在皮肤中的含量。Melanotan I 可用于辅助美黑。Melanotan I 可用于预防阳光诱发皮肤癌，可用于研究黑色素瘤和男性勃起功能障碍。
T7813	α-MSH MSH, amide,CZEN-002,美拉诺坦,α-Melanocyte-Stimulating Hormone (MSH), amide	Melanocortin Receptor; Adenylyl cyclase	GPCR/G Protein; Neuroscience
	α-MSH (MSH, amide) 是一种内源性神经肽，是一种内源性黑皮质素受体 4 (MC4R) 激动剂，具有抗炎和解热活性。
T7769	Nonapeptide-1 Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5	Others	Others
	Nonapeptide-1 (Melanostatine™ 5) 可以抑制黑色素的合成，这使得它对治疗某些皮肤病很感兴趣。
T7627	Adrenocorticotropic Hormone (ACTH) (4-10), human Adrenocorticotropic Hormone (ACTH) (4-10),ACTH (4-10), human,Acth (4-10)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Adrenocorticotropic Hormone (ACTH) (4-10), human 是黑皮质素 4 型受体 (melanocortin 4 receptor, MC4R) 激动剂。
T8231	Adrenocorticotropic Hormone (ACTH) (1-39), human ACTH (1-39), human,丝拉克肽	Others	Others
	Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH (1-39), human) 是黑皮质素受体激动剂。
TP1324	Melanotan (MT)-II 美拉诺坦 II,美拉诺坦 (MT)-II	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Melanotan (MT)-II 是一种可注射用的多肽荷尔蒙，是合成的黑皮质素受体激动剂，能够促进晒黑。
T7627L	Adrenocorticotropic Hormone (ACTH) (4-10) TFA Adrenocorticotropic Hormone (ACTH) (4-10) TFA(4037-01-8(free base)),Acth (4-10)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Adrenocorticotropic Hormone (ACTH) (4-10) TFA (Acth (4-10)) 是一种有效的黑皮质素 (MC4R) 受体激动剂。
TP1011L	ACTH (1-17) acetate	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	ACTH (1-17) acetate 是一种有效的人黑皮质素 1 (MC1) 受体激动剂，具有高亲和力 (Ki = 0.21 nM)。
T69526	PF-07258669	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	PF-07258669 是一种选择性黑皮质素 4 受体 (MC4) 拮抗剂，可用于研究恶病质和食欲衰退。
TP1004L	Beta-MSH (1-22) (human) acetate Beta-MSH (1-22) (human) acetate (17908-57-5 Free base),醋酸Β-促黑激素(人)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Beta-MSH (1-22) (human) acetate (Beta-MSH (1-22) (human) acetate (17908-57-5 Free base)) 是一种 22 肽，是一种内源性黑皮质素 4 受体 (MC4-R) 激动剂。
TP1893L1	[D-Trp8]-γ-MSH acetate(321351-81-9 free base)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	[D-Trp8]-γ-MSH acetate(321351-81-9 free base) 是选择性黑皮质素 3 (MC3) 受体激动剂（对人 MC3、MC5 和 MC4 受体的 IC50 值分别为 6.7、340 和 600 nM）。显示有抗炎功效。
T12882L	Setmelanotide Acetate(920014-72-8 free base) RM-493 Acetate,IRC-022493 Acetate,BIM-22493 Acetate	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Setmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) 是黑皮质素 4 受体 (MC4R) 的选择性激动剂（人和大鼠 MC4R，EC50 分别为 0.27 nM 和 0.28 nM）。
TP1952L	PG 106 acetate PG 106 acetate(944111-22-2 Free base)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	PG 106 acetate 是一种有效的特异性人黑皮质素 3 (hMC3) 受体拮抗剂，IC50 为 210 nM。 PG 106 acetate 对 hMC5 受体和 hMC4 受体没有活性，hMC4 受体的 EC50 为 9900 nM。
TP2212L	a-MSH, amide Acetate(581-05-5 free base)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	a-MSH, amide Acetate(581-05-5 free base) 是一种内源性黑皮质素受体 4 (MC4R) 激动剂，具有抗炎和解热活性。 α-MSH 是阿片黑皮质素原 (POMC) 的翻译后衍生物。
TP2015L	HS 014 acetate(207678-81-7 free base)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	HS 014 acetate(207678-81-7 free base) 是一种有效的选择性黑皮质素 MC4 受体拮抗剂（克隆的人 MC4、MC1、MC3 和 MC5 受体的 Ki 值分别为 3.16、108、54.4 和 694 nM）。体内中枢给药后增加大鼠的食物摄入和小鼠的伤害感受。还抑制室旁下丘脑中 IL-1β 诱导的 Fos 表达。
T25310	Dersimelagon MT-7117	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Dersimelagon (MT-7117) (MT-7117) 是一种具有口服活性的选择性黑皮质素 1 受体(MC1R) 激动剂，对人 (h)、食蟹猴 (cm)、小鼠 (m) 和大鼠 (r) MC1R 的 EC50 值分别为 8.16、3.91、1.14 和 0.251 nM。Dersimelagon 对 hMC1R 和 hMC4R 表现出良好的亲和力，Ki 值分别为 2.26 和 32.9 nM。Dersimelagon 可用于皮肤色素沉着的研究。
T22989	ML 00253764 hydrochloride	Others	Others
	melanocortin MC4 receptor antagonist
T28635	RY764 RY 764,RY-764
	RY764 is a potent and selective agonist of melanocortin subtype-4 receptor.
T24495	MPCI
	MPCI is a selective melanocortin-4 receptor antagonist.
T10251	Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA ACTH (1-39) (mouse, rat) TFA	Others	Others
	Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist.
T12072	ML-00253764 hydrochloride	Others	Others
	ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).
T33419	MK-0493 HCl MK 0493,MK-0493,MK0493
	MK-0493 is a novel, potent, and selective agonist for melanocortin receptor 4 (MC4R).
T12944	SNT-207707	Others	Others
	SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor).
T10230	MC-4R Agonist 1	Others	Others
	MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R) and can be used in the research of sexual dysfunction, obesity, and diabetes.
T12415	PF-00446687	Others	Others
	PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).
T16086	MK-0493	Others	Others
	MK-0493 is an effective and selective agonist of the melanocortin receptor 4 (MC4R). It also demonstrated significant reductions in energy intake.
TP1242	1-39-Corticotropin (human)(TFA) Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA)
	Adrenocorticotropic Hormone (ACTH) (1-39) human(TFA),a member of the melanocortin family, is a melanocortin receptor agonist. It stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and
TP1041	Setmelanotide TFA (1294000-61-5 free base) IRC-022493 TFA,BIM-22493 TFA,Setmelanotide TFA,RM-493 TFA
	Setmelanotide TFA (RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist.
T27986	MCL0129 MCL-0129,MCL 0129
	MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia.
T12946	SNT-207858	Others	Others
	SNT-207858 is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
TP1010	ACTH (1-17) (TFA) (7266-47-9 free base) α1-17-ACTH TFA,ACTH (1-17) (TFA)
	ACTH (1-17) TFA is a corticotrophin analogue and an effective human melanocortin 1 (MC1) receptor agonist with Ki value of 0.21 nM.
T12945	SNT-207858 free base	Others	Others
	SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor).
T75965	β-Melanocyte Stimulating Hormone (MSH), human TFA
	β-Melanocyte Stimulating Hormone (MSH), human TFA，为一种具有22个氨基酸残基的肽类化合物，是内源性黑皮质素-4 受体(melanocortin-4 receptor; MC4-R)的激动剂。
T75977	ACTH (1-17) (TFA)
	ACTH (1-17) TFA 是促肾上腺皮质激素类似物，是一种有效的人黑皮素受体 (human melanocortin 1 (MC1) receptor) 激动剂，Ki 值为 0.21 nM。
T69607	Dersimelagon phosphate
	Dersimelagon phosphate is a selective melanocortin-1 receptor (MC1R) agonist that increases skin melanin without sun exposure and is being developed to increase light tolerance in EPP/XLP patients.
T75848	PG106 TFA
	PG106 TFA 是一种有效的、选择性的 hMC3 receptor 拮抗剂 (IC50= 210 nM)，对 hMC4 受体(EC50=9900 nM) 和 hMC5 受体无活性。
T70838	RO27-3225 TFA
	RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival.
TP1893	[D-Trp8]-γ-MSH
	Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.
T68328	Modimelanotide
	Modimelanotide is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development for the treatment of acute kidney injury. It acts as a non-selective melanocortin receptor agonist.
TP1011	ACTH (1-17) α1-17-ACTH
	ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland.
TP2154	RO27-3225 TFA (274682-89-2 free base) RO27-3225 TFA	Others	Others
	RO27-3225 TFA is a potent and selective agonist of melanocortin 4 receptor (MC4R; EC50: 1 nM and 8 nM for MC4R and MC1R) with neuroprotective and anti-inflammatory effects. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R.
T10568	BMS-470539 dihydrochloride	Others	Others
	BMS-470539 dihydrochloride is a highly potent and selective agonist of the melanocortin-1 receptor (MC-1R; IC50: 120 nM; EC50: 28 nM) with anti-inflammatory properties. It does not activate MC-3R and is a very weak partial agonist at MC-4R and MC-5R.
T75971	γ-1-Melanocyte Stimulating Hormone (MSH), amide
	γ-1-Melanocyte Stimulating Hormone (MSH), amide为含11个氨基酸的多肽，主要通过激活黑皮质素受体3 (MC3-R) 调节钠 (Na+) 平衡及血压。
T79090	Bivamelagon MC-4R Agonist 2	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	MC-4R Agonist 2 (实施例 1)作为MC4R激动剂，适用于肥胖、糖尿病、炎症及勃起功能障碍的研究领域。

化合物

Cat.No: T8485

Target: Melanocortin Receptor

Cat.No: TP1898

Synonym: HS 024

Target: Melanocortin Receptor

Afamelanotide acetate

Cat.No: T7589

Synonym: afamelanotide

Target: Melanocortin Receptor

Cat.No: TP1889

Synonym: MCL 0020

Target: Melanocortin Receptor

Cat.No: T5464

Synonym: JNJ10229570,UNII-N9IX402L35,JNJ 10229570

Target: Melanocortin Receptor

Bremelanotide Acetate

Cat.No: T7608

Synonym: bremelanotide,PT-141 Acetate

Target: Melanocortin Receptor

Cat.No: TP1097

Synonym: 美拉诺坦,美拉诺坦 I,[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I

Target: Others

Cat.No: T7813

Synonym: MSH, amide,CZEN-002,美拉诺坦,α-Melanocyte-Stimulating Hormone (MSH), amide

Target: Melanocortin Receptor, Adenylyl cyclase

Cat.No: T7769

Synonym: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5

Target: Others

Adrenocorticotropic Hormone (ACTH) (4-10), human

Cat.No: T7627

Synonym: Adrenocorticotropic Hormone (ACTH) (4-10),ACTH (4-10), human,Acth (4-10)

Target: Melanocortin Receptor

Adrenocorticotropic Hormone (ACTH) (1-39), human

Cat.No: T8231

Synonym: ACTH (1-39), human,丝拉克肽

Target: Others

Melanotan (MT)-II

Cat.No: TP1324

Synonym: 美拉诺坦 II,美拉诺坦 (MT)-II

Target: Melanocortin Receptor

Adrenocorticotropic Hormone (ACTH) (4-10) TFA

Cat.No: T7627L

Synonym: Adrenocorticotropic Hormone (ACTH) (4-10) TFA(4037-01-8(free base)),Acth (4-10)

Target: Melanocortin Receptor

ACTH (1-17) acetate

Cat.No: TP1011L

Target: Melanocortin Receptor

Cat.No: T69526

Target: Melanocortin Receptor

Beta-MSH (1-22) (human) acetate

Cat.No: TP1004L

Synonym: Beta-MSH (1-22) (human) acetate (17908-57-5 Free base),醋酸Β-促黑激素(人)

Target: Melanocortin Receptor

[D-Trp8]-γ-MSH acetate(321351-81-9 free base)

Cat.No: TP1893L1

Target: Melanocortin Receptor

Setmelanotide Acetate(920014-72-8 free base)

Cat.No: T12882L

Synonym: RM-493 Acetate,IRC-022493 Acetate,BIM-22493 Acetate

Target: Melanocortin Receptor

Cat.No: TP1952L

Synonym: PG 106 acetate(944111-22-2 Free base)

Target: Melanocortin Receptor

a-MSH, amide Acetate(581-05-5 free base)

Cat.No: TP2212L

Target: Melanocortin Receptor

HS 014 acetate(207678-81-7 free base)

Cat.No: TP2015L

Target: Melanocortin Receptor

Cat.No: T25310

Synonym: MT-7117

Target: Melanocortin Receptor

ML 00253764 hydrochloride

Cat.No: T22989

Target: Others

Cat.No: T28635

Synonym: RY 764,RY-764

Cat.No: T24495

Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA

Cat.No: T10251

Synonym: ACTH (1-39) (mouse, rat) TFA

Target: Others

ML-00253764 hydrochloride

Cat.No: T12072

Target: Others

Cat.No: T33419

Synonym: MK 0493,MK-0493,MK0493

Cat.No: T12944

Target: Others

MC-4R Agonist 1

Cat.No: T10230

Target: Others

Cat.No: T12415

Target: Others

Cat.No: T16086

Target: Others

1-39-Corticotropin (human)(TFA)

Cat.No: TP1242

Synonym: Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA)

Setmelanotide TFA (1294000-61-5 free base)

Cat.No: TP1041

Synonym: IRC-022493 TFA,BIM-22493 TFA,Setmelanotide TFA,RM-493 TFA

Cat.No: T27986

Synonym: MCL-0129,MCL 0129

Cat.No: T12946

Target: Others

ACTH (1-17) (TFA) (7266-47-9 free base)

Cat.No: TP1010

Synonym: α1-17-ACTH TFA,ACTH (1-17) (TFA)

SNT-207858 free base

Cat.No: T12945

Target: Others

β-Melanocyte Stimulating Hormone (MSH), human TFA

Cat.No: T75965

ACTH (1-17) (TFA)

Cat.No: T75977

Dersimelagon phosphate

Cat.No: T69607

Cat.No: T75848

Cat.No: T70838

[D-Trp8]-γ-MSH

Cat.No: TP1893

Cat.No: T68328

Cat.No: TP1011

Synonym: α1-17-ACTH

RO27-3225 TFA (274682-89-2 free base)

Cat.No: TP2154

Synonym: RO27-3225 TFA

Target: Others

BMS-470539 dihydrochloride

Cat.No: T10568

Target: Others

γ-1-Melanocyte Stimulating Hormone (MSH), amide

Cat.No: T75971

Cat.No: T79090

Synonym: MC-4R Agonist 2

Target: Melanocortin Receptor

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